All Publications

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  1. The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis. Bilverstone TW, Garland M, Cave RJ, Kelly ML, Tholen M, et al.. PLOS Pathogens (September 2020) 16(9): e1008852. doi: 10.1371/journal.ppat.1008852.
  2. Carbon Recycling: Making our future sustainable. Dynes LM and Minton J. New Scientist Magazine (June 2020) Page 44 of the 20 June 2020 edition.
  3. Trends in Systems Biology for the Analysis and Engineering of Clostridium acetobutylicum Metabolism. Yoo M, Ngoc-Phuong-Thao N and Soucaille P. Trends in Microbiology (February 2020) Vol 28:2, 118-140. doi: 10.1016/j.tim.2019.09.003.
  4. Phosphorylation and functionality of CdtR in Clostridium difficile. Bilverston TW, Minton N and Kuehne SA. Anaerobe (August 2019) Volume 58. DOI:10.1016/j.anaerobe.2019.102074. 
  5. The carbonic anhydrase of Clostridium autoethanogenum represents a new subclass of β-carbonic anhydrases. Pander B, Harris G, Scott DJ, Winzer K, Köpke M, Simpson SD, Minton NP and Henstra AM. Appl Microbiol Biotechnol. (September 2019) 103(17):7275-7286. DOI:10.1007/s00253-019-10015-w.
  6. Engineering of vitamin prototrophy in Clostridium ljungdahlii and Clostridium autoethanogenum. Annan FJ, Al-Sinawi B, Humphreys CM, Norman R, Winzer K, Köpke M, Simpson SD, Minton NP and Henstra AM. Appl Microbiol Biotechnol. (April 2019) 103(11):4633-4648. DOI: 10.1007/s00253-019-09763-6. 
  7. Homologous overexpression of hydrogenase and glycerol dehydrogenase in Clostridium pasteurianum to enhance hydrogen production from crude glycerol. Sarma S, Ortega D, Minton NP, Dubey VK and Moholkar VS. Bioresour Technol. (July 2019) 284:168-177. DOI: 10.1016/j.biortech.2019.03.074. 
  8. The genetic basis of 3-hydroxypropanoate metabolism in Cupriavidus necator H16. Arenas-López C, Locker J, Orol D, Walter F, Busche T, Kalinowski J, Minton NP, Kovács K and Winzer K. Biotechnology for Biofuels. (June 2019) 12, 150. DOI: 10.1186/s13068-019-1489-5.  
  9. RiboCas: A Universal CRISPR-Based Editing Tool for Clostridium. Cañadas IC, Groothuis D, Zygouropoulou M, Rodrigues R, Minton NP. ACS Synth Biol. (June 2019) 21;8(6):1379-1390. DOI: 10.1021/acssynbio.9b00075.
  10. Nanorg Microbial Factories: Light-Driven Renewable Biochemical Synthesis Using Quantum Dot-Bacteria Nanobiohybrids. Ding Y, Bertram JR, Eckert C, Bommareddy RR, Patel R, Conradie A, Bryan S and Nagpal P. J Am Chem Soc. (June 2019) 3;141(26):10272-10282. DOI: 10.1021/jacs.9b02549. 
  11. Heterologous gene expression in the human gut bacteria Eubacterium rectale and Roseburia inulinivorans by means of conjugative plasmids. Sheridan PO, Martin JC, Minton NP, Flint HJ, O'Toole PW and Scott KP. Anaerobe. (June 2019) 19;59:131-140. DOI: 10.1016/j.anaerobe.2019.06.008.
  12. A Novel Conjugal Donor Strain for Improved DNA transfer into Clostridium spp. Woods C, Humphreys CM, Rodrigues RM, Ingle P, Rowe P, Henstra AM, Köpke M, Simpson SD, Winzer K and Minton NP. Anaerobe. (June 2019) 59:184-191. DOI: 10.1016/j.anaerobe.2019.06.020.  
  13. Proteins in Ionic Liquids: Reactions, Applications, and Futures. Schindl A, Hagen ML, Muzammal S, Gunasekera HA and Croft AK. Frontiers in Chemistry. (May 2019) 7:347. DOI: 10.3389/fchem.2019.00347. 
  14. Generation of a fully erythromycin-sensitive strain of Clostridioides difficile using a novel CRISPR-Cas9 genome editing system. Ingle P, Groothuis D, Rowe P, Huang H, Cockayne A, Kuehne SA, Jiang W, Gu Y, Humphreys CM and Minton NP. Sci Rep. (May 2019) 31;9(1):8123. DOI: 10.1038/s41598-019-44458-y. 
  15. Design, cloning and characterization of transcription factor-based inducible gene expression systems. Hanko EKR, Minton NP and Malys N. Methods in Enzymology, A. K. Shukla, ed. Elsevier. (March 2019) 621:153-169. DOI: 10.1016/bs.mie.2019.02.018. 
  16. Abundance in the Anthropocene. Giraud E, Hadley Kershaw E, Helliwell R and Hollin G. The Sociological Review. (February 2019) 67(2), 357-373. DOI: 10.1177/0038026119830907. (Published both in the journal and also in a monograph). 
  17. CRISPR-Cas9D10A nickase-assisted base editing in the solvent producer Clostridium beijerinckii. Li Q, Seys FM, Minton NP, Yang J, Jiang Y, Jiang W and Yang S. Biotechnol Bioeng. (February 2019) 116(6):1475-1483. DOI: 10.1002/bit.26949. 
  18. Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS. Dahabiyeh LA, Tooth D and Barrett DA. Analytical Biochemistry (February 2019) 567, 72-81. DOI: 10.1016/j.ab.2018.12.011. 
  19. Torulaspora delbrueckii: Towards Innovating in the Legendary Baking and Brewing Industries. Pech-Canul ÁC, Ortega D, Garcia-Triana A and Solís-Oviedo RL. Frontiers and New Trends in the Science of Fermented Food and Beverages. Publisher: IntechOpen (January 2019). DOI: 10.5772/intechopen.83522. 
  20. Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS. Dahabiyeh LA, Tooth D, Carrell RW, Read RJ, Yan Y, Broughton-Pipkin F and Barrett DA. Analytical and Bioanalytical Chemistry (January 2019) 411(2), 427-437. DOI: 10.1007/s00216-018-1455-2. 
  21. Effect of antibiotic treatment in the formation of non-spore Clostridium difficile persister-like cells. Álvarez R, Inostroza O, Garavaglia M, Minton NP, Paredes-Sabja D and Gil F. Journal of Antimicrobial Chemotherapy (September 2018). DOI: 10.1093/jac/dky186.
  22. Functional genetic elements for controlling gene expression in Cupriavidus necator H16. Alagesan S, Hanko EKR, Malys N, Ehsaan M, Winzer K, Minton NP. Applied and Environmental Microbiology (July 2018) 84:e00878-18. DOI: 10.1128/AEM.00878-18.
  23. Engineering beta-oxidation in Yarrowia lipolytica for methyl ketone production. Hanko EKR, Denby CM, Sanchez i Nogue V, Lin W, Ramirez KJ, Singer CA, Beckham GT and Keasling JD. Metab. Eng. (July 2018) 48:52-62. DOI: 10.1016/j.ymben.2018.05.018.
  24. Dispersion of relative importance values contributes to the ranking uncertainty: Sensitivity analysis of Multiple Criteria Decision-Making methods. Maliene V, Dixon-Gough R and Malys N. Applied Soft Computing Journal (June 2018) 67, pp. 286-298. DOI: 10.1016/j.asoc.2018.03.003.
  25. Upscaling diffusion through first-order volumetric sinks: a homogenization of bacterial nutrient uptake. Dalwadi MP, Wang Y, King JR, and Minton NP. SIAM Journal on Applied Mathematics. (May 2018) 78:1300—1329. DOI: 0.1137/17M1138625.
  26. A transcription factor-based biosensor for detection of itaconic acid. Hanko EKR, Minton NP and Malys N. ACS Synth. Biol. (April 2018) 7 (5):1436-1446. DOI: 10.1021/acssynbio.8b00057.
  27. The butanol producing microbe Clostridium beijerinckii NCIMB 14988 manipulated using forward and reverse genetic tools. Little GT, Willson BJ, Heap JT, Winzer K and Minton NP. Biotechnol J. (April 2018) DOI: 10.1002/biot.201700711.
  28. Progress towards platform chemical production using Clostridium autoethanogenum. Norman ROJ, Millat T, Winzer K, Minton NP and Hodgman C. Biochemical Society Transactions (April 2018) 46(3), 523-535. DOI: 10.1042/BST20170259.
  29. Quantitative isotope dilution high-resolution mass spectrometry analysis of multiple intracellular metabolites in Clostridium autoethanogenum using uniformly 13C-labelled standards derived from Spirulina. Schatschneider S, Abdelrazig S, Safo L, Henstra AM, Millat TD-H, Winzer K, Minton N, Barrett DA. Analytical Chemistry., (March 2018) DOI: 10.1021/acs.analchem.7b04758.
  30. Applying asymptotic methods to synthetic biology: modelling the reaction kinetics of the mevalonate pathway. Dalwadi MP, Garavaglia M, Webb JP, King JR, and Minton NP. J. Theoretical Bio., (February 2018) DOI: 10.1016/j.jtbi.2017.11.022.
  31. Advances in metabolic engineering in the microbial production of fuels and chemicals from C1 gas. Humphreys CM and Minton NP. Curr. Opin. Biotechnol., (January 2018) 31;50:174-181. DOI: 10.1016/j.copbio.2017.12.02.
  32. Characterization of the impact of rpoB mutations on the in vitro and in vivo competitive fitness of Clostridium difficile and susceptibility to fidaxomicin. Kuehne SA, Dempster AW, Collery MM, Joshi N, Jowett J, Kelly ML, Cave R, Longshaw CM and Minton NP. J. Antimicrob. Chemother., (December 2017) 15. DOI: 10.1093/jac/dkx486.
  33. 13C-assisted metabolic flux analysis to investigate heterotrophic and mixotrophic metabolism in Cupriavidus necator H16. Alagesan S, Minton NP and Malys N. Metabolomics, (December 2017) 14:9. DOI:10.1007/s11306-017-1302-z.
  34. Improving gene transfer in Clostridium pasteurianum through the isolation of rare hypertransformable variants. Grosse-Honebrink A, Schwarz KM, Wang H, Minton NP and Zhang Y. Anaerobe, (December 2017) 48:203-205. DOI: 10.1016/j.anaerobe.2017.09.001.
  35. Multi-timescale analysis in synthetic biology: a kinetic model for 3-hydroxypropionic acid pro- duction via betaalanine. Dalwadi MP, King JR, and Minton NP. J. Math. Biol., (November 2017) DOI: 10.1007/s00285-017-1189-3. 
  36. Mathematical modeling of chemical agent removal by reaction with an immiscible cleanser. Dalwadi MP, O’Kiely D, Thomson SJ, Khaleque TS, and Hall CL. SIAM J. Appl. Math., (November 2017) 77(6);1937–61. DOI: 10.1137/16M1101647.
  37. The effect of weak inertia in rotating high-aspect-ratio vessel bioreactors. Dalwadi MP, Chapman SJ, Oliver JM and Waters SL. J. Fluid Mechanics, (November 2017) 835;674–720 DOI: 10.1017/jfm.2017.760.
  38. Characterisation of a 3-hydroxypropionic acid-inducible system from Pseudomonas putida for orthogonal gene expression control in Escherichia coli and Cupriavidus necator. Hanko EKR, Minton NP and Malys N. Sci. Rep., (May 2017) 7:1724. DOI: 10.1038/s41598-017-01850-w.
  39. Development of Clostridium difficile R20291ΔPaLoc model strains and in vitro methodologies reveals CdtR is required for the production of CDT to cytotoxic levels. Bilverstone TW, Kinsmore NL, Minton NP and Kuehne SA. Anaerobe, (April 2017) 44:51-54. DOI:10.1016/j.anaerobe.2017.01.009.
  40. Towards improved butanol production through targeted genetic modification of Clostridium pasteurianum. Schwarz KM, Grosse-Honebrink A, Derecka K, Rotta C, Zhang Y and Minton NP. Metab Eng., (March 2017) 40:124-137. DOI:10.1016/j.ymben.2017.01.009. 
  41. Microbial solvent formation revisited by comparative genome analysis. Poehlein A, Solano JD, Flitsch SK, Krabben P, Winzer K, Reid SJ, Jones DT, Green E, Minton NP, Daniel R and Dürre P. Biotechnol Biofuels, (March 2017) 9;10:58. DOI:10.1186/s13068-017-0742-z.
  42. Metabolic engineering of Clostridium autoethanogenum for selective alcohol production. Liew F, Henstra AM, Kӧpke M, Winzer K, Simpson SD and Minton NP. Metab Eng., (March 2017) 40:104-114. DOI:10.1016/j.ymben.2017.01.007.
  43. Enhanced solvent production by metabolic engineering of a twin-clostridial consortium. Wen Z, Minton NP, Zhang Y, Li Q, Liu J, Jiang Y and Yang S. Metab Eng., (January 2017) 39:38-48. DOI:10.1016/j.ymben.2016.10.013.
  44. Development and implementation of rapid metabolic engineering tools for chemical and fuel production in Geobacillus thermoglucosidasius NCIMB 11955. Sheng L, Kovács K, Winzer K, Zhang Y and Minton NP. Biotechnol Biofuels, (January 2017) 3;10:5. DOI:10.1186/s13068-016-0692-x.
  45. Functional Intestinal Bile Acid 7α-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model. Studer N, Desharnais L, Beutler M, Brugiroux S, Terrazos MA, Menin L, Schürch CM, McCoy KD, Kuehne SA, Minton NP, Stecher B, Bernier-Latmani R and Hapfelmeier S. Front Cell Infect Microbiol., (December 2016) 20;6:191. DOI:10.3389/fcimb.2016.00191.
  46. CRISPR/Cas9-Based Efficient Genome Editing in Clostridium ljungdahlii, an Autotrophic Gas-Fermenting Bacterium. Huang H, Chai C, Li N, Rowe P, Minton NP, Yang S, Jiang W and Gu Y. ACS Synth Biol, (December 2016) 16;5(12):1355-1361. DOI:10.1021/acssynbio.6b00044.
  47. A genetic assay for gene essentiality in Clostridium. Walker DJ, Heap JT, Winzer K and Minton NP. Anaerobe, (December 2016) 42:40-43. DOI:10.1016/j.anaerobe.2016.07.007.
  48. Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection. Stevenson EC, Major GA, Spiller RC, Kuehne SA and Minton NP. J Clin Microbiol, (November 2016) 54(11):2689-2694. DOI:10.1128/JCM.01025-16.
  49. A roadmap for gene system development in Clostridium. Minton NP, Ehsaan M, Humphreys CM, Little GT, Baker J, Henstra AM, Liew F, Kelly ML, Sheng L, Schwarz K and Zhang Y. Anaerobe, (October 2016) 41:104-112. DOI:10.1016/j.anaerobe.2016.05.011. 
  50. What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives. Collery MM, Kuehne SA, McBride SM, Kelly ML, Monot M, Cockayne A, Dupuy B, Minton NP. Virulence, (September 2016) 21:1-15. DOI:10.1080/21505594.2016.1237333.
  51. Complete Genome Sequence of Geobacillus thermoglucosidasius NCIMB 11955, the Progenitor of a Bioethanol Production Strain. Sheng L, Zhang Y and Minton NP. Genome Announc, (September 2016) 29:4(5),01065-16. DOI:10.1128/genomeA.01065-16.
  52. Clostridium difficile Genome Editing Using pyrE Alleles. Ehsaan M, Kuehne SA and Minton NP. Methods Mol Biol., (August 2016) 1476:35-52. DOI:10.1007/978-1-4939-6361-4_4.
  53. The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia. Cowardin CA, Buonomo EL, Saleh MM, Wilson MG, Burgess SL, Kuehne SA, Schwan C, Eichhoff AM, Koch-Nolte F, Lyras D, Aktories K, Minton NP, Petri WA Jr. Nat Microbiol., (July 2016) 11;1(8):16108. DOI:10.1038/nmicrobiol.2016.108.
  54. CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii. Li Q, Chen J, Minton NP, Zhang Y, Wen Z, Liu J, Yang H, Zeng Z, Ren X, Yang J, Gu Y, Jiang W, Jiang Y and Yang S. Biotechnol J, (July 2016) 11(7):961-72. DOI:10.1002/biot.201600053.
  55. SBRC-Nottingham: sustainable routes to platform chemicals from C1 waste gases. Burbidge A, Minton NP. Biochem Soc Trans., (June 2016) 15;44(3):684-6. DOI:10.1042/BST20160010.
  56. Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection. Kelly ML, Ng YK, Cartman ST, Collery MM, Cockayne A, Minton NP. Anaerobe, (June 2016) 39:51-3. DOI:10.1016/j.anaerobe.2016.02.011.
  57. Production of a functional cell wall-anchored minicellulosome by recombinant Clostridium acetobutylicum ATCC 824. Willson BJ, Kovács K, Wilding-Steele T, Markus R, Winzer K, Minton NP. Biotechnol Biofuels, (May 2016) 23;9:109. DOI:10.1186/s13068-016-0526-x.
  58. Insights into CO2 Fixation Pathway of Clostridium autoethanogenum by Targeted Mutagenesis. Liew F, Henstra AM, Winzer K, Köpke M, Simpson SD, Minton NP. MBio., (May 2016) 24;7(3). DOI:10.1128/mBio.00427-16.
  59. Development of an inducible transposon system for efficient random mutagenesis in Clostridium acetobutylicum. Zhang Y, Xu S, Chai C, Yang S, Jiang W, Minton NP, Gu Y. FEMS Microbiol Lett, (April 2016) 363(8). DOI:10.1093/femsle/fnw065.
  60. The dilemma of raising awareness “responsibly”. The need to discuss controversial research with thepublic raises a conundrum for scientists: when is the right time to start public debates? Nerlich B and McLeod C. EMBO Reports, (March 2016) 17:4, 481-485. DOI: 10.15252/embr.201541853.
  61. Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress. Mowday AM, Guise CP, Ackerley DF, Minton NP, Lambin P, Dubois LJ, Theys J, Smaill JB and Patterson AV. Cancers (Basel), (February 2016) 8(7), 63. DOI:10.3390/cancers8070063.
  62. Clostridium difficile-mediated effects on human intestinal epithelia: Modelling host-pathogen interactions in a vertical diffusion chamber. Jafari NV, Kuehne SA, Minton NP, Allan E and Bajaj-Elliott M. Anaerobe, (February 2016) 37:96-102. DOI:doi.org/10.1016/j.anaerobe.2015.12.007.
  63. Mutant generation by allelic exchange and genome resequencing of the biobutanol organism Clostridium acetobutylicum ATCC 824. Ehsaan M, Kuit W, Zhang Y, Cartman ST, Heap JT, Winzer K, Minton NP. Biotechnol Biofuels, (January 2016) 4;9:4. DOI:10.1186/s13068-015-0410-0. 
  64. Whole genome sequence and manual annotation of Clostridium autoethanogenum, an industrially relevant bacterium. Humphreys CM, McLean S, Schatschneider S, Millat T, Henstra AM, Annan FJ, Breitkopf R, Pander B, Piatek P, Rowe P, Wichlacz AT, Woods C, Norman R, Blom J, Goesman A, Hodgman C, Barrett D, Thomas NR, Winzer K and Minton NP. BMC Genomics, (December 2015) 16:1085. DOI: 10.1186/s12864-015-2287-5.

 

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