Publications

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2017

Microbial solvent formation revisited by comparative genome analysis. Poehlein A, Solano JD, Flitsch SK, Krabben P, Winzer K, Reid SJ, Jones DT, Green E, Minton NP, Daniel R, Dürre P.Biotechnol Biofuels. 2017 Mar 9;10:58. doi: 10.1186/s13068-017-0742-z. eCollection 2017.PMID: 28286553.

Towards improved butanol production through targeted genetic modification of Clostridium pasteurianum. Schwarz KM, Grosse-Honebrink A, Derecka K, Rotta C, Zhang Y, Minton NP.Metab Eng. 2017 Mar;40:124-137. doi: 10.1016/j.ymben.2017.01.009. Epub 2017 Jan 22.PMID: 28119139

Development of Clostridium difficile R20291ΔPaLoc model strains and in vitro methodologies reveals CdtR is required for the production of CDT to cytotoxic levels. Bilverstone, T.W., N.L. Kinsmore, N.P. Minton, and S.A. Kuehne Anaerobe, 2017. 44: p. 51-54. DOI: http://dx.doi.org/10.1016/j.anaerobe.2017.01.009.

Metabolic engineering of Clostridium autoethanogenum for selective alcohol production. Liew F, Henstra AM, Kӧpke M, Winzer K, Simpson SD, Minton NP.Metab Eng. 2017 Mar;40:104-114. doi: 10.1016/j.ymben.2017.01.007. Epub 2017 Jan 19.PMID: 28111249

Functional Intestinal Bile Acid 7α-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model. Studer N, Desharnais L, Beutler M, Brugiroux S, Terrazos MA, Menin L, Schürch CM, McCoy KD, Kuehne SA, Minton NP, Stecher B, Bernier-Latmani R, Hapfelmeier S.Front Cell Infect Microbiol. 2016 Dec 20;6:191. doi: 10.3389/fcimb.2016.00191. eCollection 2016.PMID: 28066726

Development and implementation of rapid metabolic engineering tools for chemical and fuel production in Geobacillus thermoglucosidasius NCIMB 11955. Sheng L, Kovács K, Winzer K, Zhang Y, Minton NP.Biotechnol Biofuels. 2017 Jan 3;10:5. doi: 10.1186/s13068-016-0692-x. eCollection 2017.PMID: 28066509

A genetic assay for gene essentiality in Clostridium. Walker DJ, Heap JT, Winzer K, Minton NP.Anaerobe. 2016 Dec;42:40-43. doi: 10.1016/j.anaerobe.2016.07.007. Epub 2016 Jul 31.PMID: 27487328

Enhanced solvent production by metabolic engineering of a twin-clostridial consortium. Wen Z, Minton NP, Zhang Y, Li Q, Liu J, Jiang Y, Yang S.Metab Eng. 2017 Jan;39:38-48. doi: 10.1016/j.ymben.2016.10.013. Epub 2016 Oct 27.PMID: 27794465 

2016

Complete Genome Sequence of Geobacillus thermoglucosidasius NCIMB 11955, the Progenitor of a Bioethanol Production Strain. Sheng L, Zhang Y, Minton NP.Genome Announc. 2016 Sep 29;4(5). pii: e01065-16. doi: 10.1128/genomeA.01065-16.PMID: 27688322

What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives. Collery MM, Kuehne SA, McBride SM, Kelly ML, Monot M, Cockayne A, Dupuy B, Minton NP.Virulence. 2016 Sep 21:1-15. doi: 10.1080/21505594.2016.1237333. [Epub ahead of print]PMID: 27652799

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia. Cowardin CA, Buonomo EL, Saleh MM, Wilson MG, Burgess SL, Kuehne SA, Schwan C, Eichhoff AM, Koch-Nolte F, Lyras D, Aktories K, Minton NP, Petri WA Jr.Nat Microbiol. 2016 Jul 11;1(8):16108. doi: 10.1038/nmicrobiol.2016.108.PMID: 27573114

Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection. Stevenson EC, Major GA, Spiller RC, Kuehne SA, Minton NP.J Clin Microbiol. 2016 Nov;54(11):2689-2694. Epub 2016 Aug 24.PMID: 27558181

Clostridium difficile Genome Editing Using pyrE Alleles. Ehsaan M, Kuehne SA, Minton NP.Methods Mol Biol. 2016;1476:35-52. doi: 10.1007/978-1-4939-6361-4_4.PMID: 27507332

Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress. Mowday AM, Guise CP, Ackerley DF, Minton NP, Lambin P, Dubois LJ, Theys J, Smaill JB, Patterson AV.Cancers (Basel). 2016 Jun 28;8(7). pii: E63. doi: 10.3390/cancers8070063. Review.PMID: 27367731

SBRC-Nottingham: sustainable routes to platform chemicals from C1 waste gases. Burbidge A, Minton NP.Biochem Soc Trans. 2016 Jun 15;44(3):684-6. doi: 10.1042/BST20160010. Review.PMID: 27284026

CRISPR/Cas9-Based Efficient Genome Editing in Clostridium ljungdahlii, an Autotrophic Gas-Fermenting Bacterium. Huang H, Chai C, Li N, Rowe P, Minton NP, Yang S, Jiang W, Gu Y.ACS Synth Biol. 2016 Dec 16;5(12):1355-1361. Epub 2016 Jun 15.PMID: 27276212

A roadmap for gene system development in Clostridium. Minton NP, Ehsaan M, Humphreys CM, Little GT, Baker J, Henstra AM, Liew F, Kelly ML, Sheng L, Schwarz K, Zhang Y.Anaerobe. 2016 Oct;41:104-112. doi: 10.1016/j.anaerobe.2016.05.011. Epub 2016 May 24. Review.PMID: 27234263 

Production of a functional cell wall-anchored minicellulosome by recombinant Clostridium acetobutylicum ATCC 824. Willson BJ, Kovács K, Wilding-Steele T, Markus R, Winzer K, Minton NP.Biotechnol Biofuels. 2016 May 23;9:109. doi: 10.1186/s13068-016-0526-x. eCollection 2016.PMID: 27222664

Insights into CO2 Fixation Pathway of Clostridium autoethanogenum by Targeted Mutagenesis. Liew F, Henstra AM, Winzer K, Köpke M, Simpson SD, Minton NP.MBio. 2016 May 24;7(3). pii: e00427-16. doi: 10.1128/mBio.00427-16.PMID: 27222467

CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii. Li Q, Chen J, Minton NP, Zhang Y, Wen Z, Liu J, Yang H, Zeng Z, Ren X, Yang J, Gu Y, Jiang W, Jiang Y, Yang S.Biotechnol J. 2016 Jul;11(7):961-72. doi: 10.1002/biot.201600053. Epub 2016 Jun 13.PMID: 27213844

Development of an inducible transposon system for efficient random mutagenesis in Clostridium acetobutylicum. Zhang Y, Xu S, Chai C, Yang S, Jiang W, Minton NP, Gu Y.FEMS Microbiol Lett. 2016 Apr;363(8). pii: fnw065. doi: 10.1093/femsle/fnw065. Epub 2016 Mar 20.PMID: 27001972

Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection. Kelly ML, Ng YK, Cartman ST, Collery MM, Cockayne A, Minton NP.Anaerobe. 2016 Jun;39:51-3. doi: 10.1016/j.anaerobe.2016.02.011. Epub 2016 Mar 2.PMID: 26946361

Mutant generation by allelic exchange and genome resequencing of the biobutanol organism Clostridium acetobutylicum ATCC 824. Ehsaan M, Kuit W, Zhang Y, Cartman ST, Heap JT, Winzer K, Minton NP.Biotechnol Biofuels. 2016 Jan 4;9:4. doi: 10.1186/s13068-015-0410-0. eCollection 2016.PMID: 26732067

Clostridium difficile-mediated effects on human intestinal epithelia: Modelling host-pathogen interactions in a vertical diffusion chamber. Jafari NV, Kuehne SA, Minton NP, Allan E, Bajaj-Elliott M.Anaerobe. 2016 Feb;37:96-102. doi: 10.1016/j.anaerobe.2015.12.007. Epub 2015 Dec 19.PMID: 26708704

 

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